We were the first research group internationally to show human skeletal muscle possesses an epigenetic memory of muscle growth (hypertrophy) after exercise.
We use various cutting-edge methods in our laboratories to do these investigations, including; research of exercise and disuse in humans and the use of muscle stem cells cultured from tissue biopsies made into tissue engineered 3D mini-muscles in culture. We also use cutting edge cell and molecular biology techniques including multi ‘OMIC’ analysis (across the entire g
Current Collaborations & Projects
Professors Truls Raastad and Olivier Seynnes at NIH, Norway - the muscle physiology and cell/molecular biology of repeated muscle loss in humans and epigenetic memory of steroids.
Dr. Tormod Nilsen at NIH, Norway - the epigenetics of exercise in breast cancer survivors.
Professor Sue Bodine and Dr. David Hughes (Assistant Research Professor) The University of Iowa, USA- investigating a gene called UBR5 that the research group previously demonstrated was a muscle ‘memory’ gene, and now in collaboration have identified UBR5 is important in protein synthesis and degradation in regulating skeletal muscle mass.
Dr. Simone Porcelli at the University of Padua, Italy - an epigenetic memory of high intensity exercise in humans.
Dr. Michael Roberts - University of Auburn, USA - the epigenetic response to resistance exercise in humans.
Dr. Jose Areta - Liverpool John Moores University, UK - epigenetics of energy availability and exercise in human skeletal muscle.
Dr Juha Hulmi - University of Jyväskylä, Finland - interaction between metabolomics and epigenomics in response to exercise stimuli using three-dimensional (3D) tissue engineered muscle in culture.
enome).
We currently have 10 million NOK funding from the Research Council of Norway for our research group to investigate if human muscle remembers periods of wasting. The research also will identify key targets and strategies (gene therapies tested in model systems) to help the elderly recover from muscle wasting (due to an injury, or hospitalisation) and prevent muscle wasting elderly individuals encounter another injury in the future.
Teaching
Responsibility for THP301 Cell Biology and MA411 Specialisation in Physiology.
Professor Adam Sharples is the main editor for the only current book in the field Molecular Exercise Physiology entitled: Molecular Exercise Physiology: An Introduction (2nd Edition) that is in press with Routledge publishers and will be released in April 2022.
Members of group
- adams@nih.no
- Phone
- +47 23 26 23 03
- danieltu@nih.no
- Phone
- +47 23 26 23 32
- danielto@nih.no
- Phone
- +47 23 26 23 41