Thomas Halvorsen

• Tveiten, Lars; Diep, Lien My; Halvorsen, Thomas & Markestad, Trond (2024). Normal range and risk factors for deviating body temperatures during the first 24 hours in term-born infants under standardised care: an observational study. BMJ Paediatrics Open. ISSN 2399-9772. 8(1). doi: 10.1136/bmjpo-2024-002596. Vis sammendrag

  Objective Body temperature for a known ambient temperature is not known for infants born at term. We aimed to determine the normal range and the incidences of hypothermia and hyperthermia during the first 24 hours of life in healthy term-born infants nursed according to WHO recommendations. Design Prospective observational study. Setting Norwegian single centre district hospital. Infants were observed during skin-to-skin care or when dressed in cots. Participants Convenience sample of 951 healthy infants born at term. Methods Delivery room temperature was aimed at 26–30°C and rooming-in temperature at 24°C. We measured rectal and room temperatures at 2, 4, 8, 16 and 24 hours of age. Main outcome measures Percentile curves for rectal temperature. Proportions and risk factors for hypothermia and hyperthermia. Results The mean (SD) room temperature was 24.0°C (1.1), 23.8°C (1.0), 23.8°C (1.0)., 23.7°C (0.9) and 23.8°C (0.9). The median (2.5, 97.5 percentile) rectal temperature was 36.9°C (35.7–37.9), 36.8°C (35.9–37.5), 36.9°C (36.1–37.5), 37.0°C (36.4–37.7) and 37.1°C (36.5–37.7). Hypothermia (37.5°C) occurred in 12% and most commonly in large infants after 8 hours of life. Risk factors for hyperthermia were high birth weight (OR 2.2 (95% CI, 1.4 to 3.5), per kg), being awake, nursed skin to skin and being born through heavily stained amniotic fluid. Conclusions Term-born infants were at risk of hypothermia during the first hours after birth even when nursed in an assumed adequate thermal environment and at risk of hyperthermia after 8 hours of age.

• Carlsen, Petter Helø; Muralitharan, Praveen; Fenne, Hilde; Jansrud, Ida; Engan, Mette & Vollsæter, Maria [Vis alle 10 forfattere av denne artikkelen] (2024). Laryngeal response to high-intensity exercise in healthy athletes. BMJ Open sport & exercise medicine. ISSN 2055-7647. 10(2). doi: 10.1136/bmjsem-2023-001850.
• Benestad, Merete; Drageset, Jorunn; Vollsæter, Maria; Hufthammer, Karl Ove; Halvorsen, Thomas & Vederhus, Bente Johanne (2024). Health-related quality of life in two birth cohorts of extremely preterm born adults. Acta Paediatrica. ISSN 0803-5253. doi: 10.1111/apa.17146.
• Lillebøe, Henriette Lahn-Johannessen; Engeseth, Merete Salveson; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas; Røksund, Ola Drange & Potrebny, Thomas [Vis alle 7 forfattere av denne artikkelen] (2024). Expiratory airflow limitation in adults born extremely preterm: A systematic review and meta-analysis. Paediatric Respiratory Reviews. ISSN 1526-0542. doi: 10.1016/j.prrv.2024.02.002.
• Simpson, Shannon J; Du Berry, Cassidy; Evans, Denby J; Gibbons, James T D; Vollsæter, Maria & Halvorsen, Thomas [Vis alle 14 forfattere av denne artikkelen] (2023). Unravelling the respiratory health path across the lifespan for survivors of preterm birth. The Lancet Respiratory Medicine. ISSN 2213-2600. doi: 10.1016/S2213-2600(23)00272-2.
• Fretheim-Kelly, Zoe; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Hilland, Magnus; Vollsæter, Maria & Halvorsen, Thomas (2023). Translaryngeal Resistance: A Measurement to Assist Decision Making in Upper Airway Pathology. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 208(6), s. E32–E34. doi: 10.1164/rccm.202205-0961IM.
• Leong, Paul; Vertigan, Anne E.; Hew, Mark; Baxter, Malcolm; Phyland, Debra & Hull, James H. [Vis alle 14 forfattere av denne artikkelen] (2023). Diagnosis of vocal cord dysfunction/inducible laryngeal obstruction: an International Delphi Consensus Study. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. doi: 10.1016/j.jaci.2023.06.007.
• Rogde, Åse Johnsen; Lehmann, Sverre; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange & Hufthammer, Karl Ove [Vis alle 9 forfattere av denne artikkelen] (2023). Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study. BMJ Open. ISSN 2044-6055. 13(6). doi: 10.1136/bmjopen-2022-071159. Fulltekst i vitenarkiv
• Budal, Elisabeth Berge; Bentsen, Mariann; Kessler, Jørg; Ebbing, Cathrine; Lindemann, Paul Christoffer & Haugen, Olav H. [Vis alle 10 forfattere av denne artikkelen] (2023). Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome. Journal of Maternal-Fetal & Neonatal Medicine. ISSN 1476-7058. 36(1). doi: 10.1080/14767058.2023.2196599.
• Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Jonsson, Grete; Dalen, Ingvild; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2023). Are BMI and adipokines associated with asthma, atopy and lung function in young adults previously hospitalized for bronchiolitis? Respiratory Medicine. ISSN 0954-6111. 209(April 2023). doi: 10.1016/j.rmed.2023.107149.
• Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Dalen, Ingvild; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2023). Blood eosinophils during bronchiolitis: Associations with atopy, asthma and lung function in young adults. Acta Paediatrica. ISSN 0803-5253. 112(4), s. 820–829. doi: 10.1111/apa.16666.
• Muralitharan, Praveen; Carlsen, Petter; Hilland, Magnus; Delestre-Levai, Irisz; Vollsæter, Maria & Hufthammer, Karl Ove [Vis alle 10 forfattere av denne artikkelen] (2023). Use of inhaled ipratropium bromide to improve exercise-induced laryngeal obstruction cannot be recommended. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 9(1). doi: 10.1183/23120541.00308-2022. Fulltekst i vitenarkiv Vis sammendrag

  Introduction: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young adults. Current management generally consists of breathing advice, speech therapy, inspiratory muscle training or supraglottoplasty in highly motivated subjects with supraglottic collapse. Inhaled ipratropium bromide (IB) is a muscarinic receptor antagonist used to treat asthma that is suggested in a few reports to improve EILO symptoms. The aim of the present study was to investigate effects of inhaled IB in EILO diagnosed by continuous laryngoscopy exercise (CLE) test and classified by CLE scores. Methods: A randomised crossover trial was conducted at Haukeland University Hospital, Bergen, Norway, enrolling participants diagnosed with EILO defined by characteristic symptoms and CLE score ≥3 (range 0–12). Two consecutive CLE tests were performed within 2 weeks, one test with and one test without prior administration of inhaled IB in a randomised order. Main outcomes were the CLE score, dyspnoea measured using a modified BORG scale (range 0–10) and cardiopulmonary exercise data provided by the CLE test. Results: 20 participants (14 females) aged 12–25 years participated, and all ran to exhaustion on both tests. Mean CLE score, BORG score and peak oxygen consumption were similar in tests performed with and without IB; mean differences (95% confidence interval) were 0.08 (−0.28–0.43), 0.35 (−0.29–0.99) and −0.4 (−1.9–1.1) mL·kg−1·min−1, respectively. Conclusion: Inhaled IB did not improve CLE score, dyspnoea or exercise capacity in subjects with EILO. The study does not support the use of inhaled IB to treat EILO.

• Benestad, Merete; Drageset, Jorunn; Hufthammer, Karl Ove; Vollsæter, Maria; Halvorsen, Thomas & Vederhus, Bente Johanne (2022). Long-term follow-up of self-reported mental health and health-related quality of life in adults born extremely preterm. Early Human Development. ISSN 0378-3782. 173. doi: 10.1016/j.earlhumdev.2022.105661. Fulltekst i vitenarkiv Vis sammendrag

  Background Survival of extremely preterm (EP) birth is increasing, but long-term consequences are still largely unknown as their high survival rates are recent achievements. Aims To examine self-reported mental health, and health related quality of life (HRQoL) in a cohort of adults born EP in the early 1990s and individually matched term-born controls, and to describe development through the transition from teenager to adults. Methods Thirty-five eligible subjects were born at gestational age ≤ 28 weeks or with birth weight ≤ 1000 g during 1991–1992 in this population-based cohort from Western Norway. We assessed mental health using Youth Self-Report (YSR) at 18 years of age, and Adult Self-Report (ASR) at 27 years, and HRQoL by RAND-36 at 27 years. Data were analysed by unadjusted and adjusted mixed effects models with time by group as interaction term. Results At 27 years, 24 (69 %) EP-born and 26 (74 %) term-born controls participated. Scores for internalising problems, and syndrome scale anxious/depressed and withdrawn were higher among EP-born compared to term-born controls. For HRQoL, scores were similar in EP-born and term-born groups, except the domain physical functioning where EP-born scored lower. Development over time from 18 to 27 years showed increasing (i.e. deteriorating) scores for internalising, anxious/depressed, somatic complaints, and attention problems in the EP born group. For the term-born, scores for anxious/depression increased over time. Conclusions At 27 years of age, EP-born adults reported more internalising problems than term-born controls, while HRQoL was relatively similar except physical functioning. Mental health problems in the EP-born increased from adolescence to adulthood.

• Bernhardsen, Guro Pauck; Stang, Julie; Halvorsen, Thomas & Stensrud, Trine (2022). Differences in lung function, bronchial hyperresponsiveness and respiratory health between elite athletes competing in different sports. European Journal of Sport Science (EJSS). ISSN 1746-1391. doi: 10.1080/17461391.2022.2113144. Fulltekst i vitenarkiv Vis sammendrag

  The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team athletes (30 swimmers, 32 cross-country skiers, 16 speed-skaters, 11 rowers/paddlers, 17 handball players and 23 soccer players) completed a validated questionnaire, measured exhaled nitric oxide (FENO), spirometry, methacholine provocation (PD20met) and skin prick test. Three cut-off levels defined BHR; i.e. PD20met ≤2 µmol, ≤4 µmol and ≤8 µmol. Mean forced vital capacity (FVC) was highest in swimmers (Mean z-score[95%CI]  = 1.16 [0.80, 1.51]), and close to or higher than reference values according to the Global Lung Initiative equation, across all sports. Mean forced expiratory volume in 1 s (FEV1) was higher than reference values in swimmers (0.48 [0.13, 0.84]), and ball game athletes (0.69 [0.41, 0.97]). Mean forced expiratory flow between 25 and 75% of FVC (FEF25-75), and/or FEV1/FVC were lower than reference values in all endurance groups. BHR defined by ≤2 and ≤8 µmol methacholine was observed in respectively 50%–87% of swimmers, 25%–47% of cross-country skiers, 20%–53% of speed-skaters, 18%–36% of rowers/paddlers, and 0%–17% of the ball game athletes. Exercise-induced symptoms were common in all groups, most frequent in cross-country skiers (88%), swimmers (83%) and speed-skaters (81%).

• Brekka, Anne Kristine; Vollsæter, Maria; Ntoumenopoulos, George; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas & Røksund, Ola Drange [Vis alle 7 forfattere av denne artikkelen] (2022). Adjustments of non-invasive ventilation and mechanically assisted cough by combining ultrasound imaging of the larynx with transnasal fibre-optic laryngoscopy: A protocol for an experimental study. BMJ Open. ISSN 2044-6055. 12(5), s. 1–7. doi: 10.1136/bmjopen-2021-059234.
• Clemm, Hege Synnøve Havstad; Olin, J Tod; McIntosh, Cameron; Schwellnus, Martin; Sewry, Nicola & Hull, James H. [Vis alle 7 forfattere av denne artikkelen] (2022). Exercise-induced laryngeal obstruction (EILO) in athletes: a narrative review by a subgroup of the IOC Consensus on 'acute respiratory illness in the athlete'. British Journal of Sports Medicine. ISSN 0306-3674. 56(11), s. 622–629. doi: 10.1136/bjsports-2021-104704. Fulltekst i vitenarkiv
• Benestad, Merete; Drageset, Jorunn; Eide, Geir Egil; Vollsæter, Maria; Halvorsen, Thomas & Vederhus, Bente Johanne (2022). Development of health-related quality of life and subjective health complaints in adults born extremely preterm: a longitudinal cohort study. Health and Quality of Life Outcomes. ISSN 1477-7525. 20, s. 1–11. doi: 10.1186/s12955-022-02018-5. Fulltekst i vitenarkiv
• Jansrud, Ida; Halvorsen, Thomas; Vollsæter, Maria; Hilland, Magnus; Heimdal, John-Helge & Røksund, Ola Drange [Vis alle 7 forfattere av denne artikkelen] (2022). Conundrums in the breathless athlete; exercise-induced laryngeal obstruction or asthma? Scandinavian Journal of Medicine & Science in Sports. ISSN 0905-7188. 32(6), s. 1041–1049. doi: 10.1111/sms.14137. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but often confused. We aimed to address this diagnostic challenge and its consequences in elite athletes. Methods: We included all athletes competing at national or international level, referred to our institution for workup for EILO during 2013–2016. We diagnosed EILO from video-recorded laryngoscopy performed during maximal cardiopulmonary treadmill exercise (CLE test). Symptoms and previous diagnostic evaluations were obtained from referral letters and chart reviews. Results: Exercise-induced laryngeal obstruction was diagnosed in 73/101 referred athletes, of whom 70/73 had moderate/severe supraglottic obstruction and 3/73 had primarily glottic obstruction with only minor supraglottic involvement. Of the 73 athletes with EILO, we were able to identify objective tests for asthma in 55 participants, of whom 22 had findings supporting asthma. However, 58/73 had used asthma therapy at some time previously, with current use in 28. Only three reported that asthma medication had improved their exercise-related breathing problems, two of whom with tests confirming asthma. Treatment for EILO improved breathing problems in all but four. Conclusions: Objective testing verified EILO in most of the referred athletes. EILO coexisting with asthma was common, and large proportions had used asthma medication; however, few reported effect on exercise-related breathing problems. Unexplained persistent exertional dyspnea must not lead to indiscriminate escalation of asthma treatment, but instead incite investigation for EILO, either as a co-morbidity or as a differential diagnosis.

• Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Dalen, Ingvild; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2022). Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: Impact of virus and sex. BMJ Open Respiratory Research. ISSN 2052-4439. 9(1). doi: 10.1136/bmjresp-2021-001095.
• Male, Christoph; Neubert, Antje; Grytli, Helene Hartvedt; Gradwohl, Christina; Strommer, Barbara & Lagler, Florian B. [Vis alle 10 forfattere av denne artikkelen] (2022). Evidence-based off-label use of drugs for children and adolescents: International consortium of pediatric formularies providing the best-available evidence. Monatsschrift fur Kinderheilkunde. ISSN 0026-9298. 170(3), s. 207–216. doi: 10.1007/s00112-022-01418-7.
• Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Andersen, Tiina Maarit; Heimdal, John-Helge; Karlsen, Tom & Hilland, Magnus [Vis alle 12 forfattere av denne artikkelen] (2022). Exercise-induced Laryngeal Obstruction: Protocol for a Randomized Controlled Treatment Trial. Frontiers in pediatrics. ISSN 2296-2360. 10. doi: 10.3389/fped.2022.817003. Fulltekst i vitenarkiv Vis sammendrag

  Background: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by continuous visualization of the larynx during high-intensity exercise. Empirical data suggest that EILO consists of different subtypes, possibly requiring different therapeutic approaches. Currently applied treatments do not rest on randomized controlled trials, and international guidelines based on good evidence can therefore not be established. This study aims to provide evidence-based information on treatment schemes commonly applied in patients with EILO. Methods and Analysis: Consenting patients consecutively diagnosed with EILO at Haukeland University Hospital will be randomized into four non-invasive treatment arms, based on promising reports from non-randomized studies: (A) standardized information and breathing advice only (IBA), (B) IBA plus inspiratory muscle training, (C) IBA plus speech therapy, and (D) IBA plus inspiratory muscle training and speech therapy. Differential effects in predefined EILO subtypes will be addressed. Patients failing the non-invasive approach and otherwise qualifying for surgical treatment by current department policy will be considered for randomization into (E) standard or (F) minimally invasive laser supraglottoplasty or (G) no surgery. Power calculations are based on the main outcomes, laryngeal adduction during peak exercise, rated by a validated scoring system before and after the interventions. Ethics and Dissemination: The study will assess approaches to EILO treatments that despite widespread use, are insufficiently tested in structured, verifiable, randomized, controlled studies, and is therefore considered ethically sound. The study will provide knowledge listed as a priority in a recent statement issued by the European Respiratory Society, requested by clinicians and researchers engaged in this area, and relevant to 5–7% of young people. Dissemination will occur in peer-reviewed journals, at relevant media platforms and conferences, and by engaging with patient organizations and the healthcare bureaucracy.

• Bårdsen, Tonje; Røksund, Ola Drange; Benestad, Merete; Hufthammer, Karl Ove; Clemm, Hege Synnøve Havstad & Mikalsen, Ingvild Bruun [Vis alle 10 forfattere av denne artikkelen] (2022). Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight. Thorax. ISSN 0040-6376. 77(8), s. 790–798. doi: 10.1136/thoraxjnl-2021-218400. Fulltekst i vitenarkiv
• Halvorsen, Thomas & Røksund, Ola Drange (2022). A novel validated tool to score symptom burden in exercise-induced laryngeal obstruction: can we simplify patient follow-up and research? The Lancet Respiratory Medicine. ISSN 2213-2600. 10(2), s. 131–132. doi: 10.1016/S2213-2600(22)00019-4.
• Fretheim-Kelly, Zoe; Engan, Mette; Clemm, Hege Synnøve Havstad; Andersen, Tiina Maarit; Heimdal, John-Helge & Strand, Eric [Vis alle 9 forfattere av denne artikkelen] (2022). Reliability of translaryngeal airway resistance measurements during maximal exercise. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 8(1), s. 1–9. doi: 10.1183/23120541.00581-2021. Fulltekst i vitenarkiv
• Ekanger, Camilla Tvedt; Zhou, Fan; Bohan, Dana; Lotsberg, Maria Lie; Ramnefjell, Maria & Hoareau, Laurence [Vis alle 21 forfattere av denne artikkelen] (2022). Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus. Frontiers in Cellular and Infection Microbiology. ISSN 2235-2988. 12, s. 1–23. doi: 10.3389/fcimb.2022.841447.
• Engan, Mette; Engeset, Merete Salveson; Sandvik, Lorentz; Gamlemshaug, Ole Christer Oma; Engesæter, Ingvild Øvstebø & Øymar, Knut Asbjørn Alexander [Vis alle 11 forfattere av denne artikkelen] (2022). Left vocal cord paralysis, lung function and exercise capacity in young adults born extremely preterm with a history of neonatal patent ductus arteriosus surgery—A national cohort study. Frontiers in pediatrics. ISSN 2296-2360. 9. doi: 10.3389/fped.2021.780045. Fulltekst i vitenarkiv Vis sammendrag

  Background: Left vocal cord paralysis (LVCP) is a known complication of patent ductus arteriosus (PDA) surgery in extremely preterm (EP) born neonates; however, consequences of LVCP beyond the first year of life are insufficiently described. Both voice problems and breathing difficulties during physical activity could be expected with an impaired laryngeal inlet. More knowledge may improve the follow-up of EP-born subjects who underwent PDA surgery and prevent confusion between LVCP and other diagnoses. Objectives: Examine the prevalence of LVCP in a nationwide cohort of adults born EP with a history of PDA surgery, and compare symptoms, lung function, and exercise capacity between groups with and without LVCP, and vs. controls born EP and at term. Methods: Adults born EP (<28 weeks' gestation or birth weight <1,000 g) in Norway during 1999–2000 who underwent neonatal PDA surgery and controls born EP and at term were invited to complete questionnaires mapping voice-and respiratory symptoms, and to perform spirometry and maximal treadmill exercise testing. In the PDA-surgery group, exercise tests were performed with a laryngoscope positioned to evaluate laryngeal function. Results: Thirty out of 48 (63%) eligible PDA-surgery subjects were examined at mean (standard deviation) age 19.4 (0.8) years, sixteen (53%) had LVCP. LVCP was associated with self-reported voice symptoms and laryngeal obstruction during exercise, not with lung function or peak oxygen consumption (VO2peak). In the PDA-surgery group, forced expiratory volume in 1 second z-score (z-FEV1) was reduced compared to EP-born controls (n = 30) and term-born controls (n = 36); mean (95% confidence interval) z-FEV1 was −1.8 (−2.3, −1.2), −0.7 (−1.1, −0.3) and −0.3 (−0.5, −0.0), respectively. For VO2peak, corresponding figures were 37.5 (34.9, 40.2), 38.1 (35.1, 41.1), and 43.6 (41.0, 46.5) ml/kg/min, respectively. Conclusions: LVCP was common in EP-born young adults who had undergone neonatal PDA surgery. Within the PDA-surgery group, LVCP was associated with self-reported voice symptoms and laryngeal obstruction during exercise, however we did not find an association with lung function or exercise capacity. Overall, the PDA-surgery group had reduced lung function compared to EP-born and term-born controls, whereas exercise capacity was similarly reduced for both the PDA-surgery and EP-born control groups when compared to term-born controls.

• Vollsæter, Maria; Stensrud, Trine; Maat, Robert; Halvorsen, Thomas; Røksund, Ola Drange & Sandnes, Astrid [Vis alle 7 forfattere av denne artikkelen] (2022). Exercise related respiratory problems in the young—Is it exercise-induced bronchoconstriction or laryngeal obstruction? Frontiers in pediatrics. ISSN 2296-2360. 9. doi: 10.3389/fped.2021.800073. Fulltekst i vitenarkiv Vis sammendrag

  Complaints of breathlessness during heavy exercise is common in children and adolescents, and represent expressions of a subjective feeling that may be difficult to verify and to link with specific diagnoses through objective tests. Exercise-induced asthma and exercise-induced laryngeal obstruction are two common medical causes of breathing difficulities in children and adolescents that can be challenging to distinguish between, based only on the complaints presented by patients. However, by applying a systematic clinical approach that includes rational use of tests, both conditions can usually be diagnosed reliably. In this invited mini-review, we suggest an approach we find feasible in our everyday clinical work.

• Rogde, Åse Johnsen; Lehmann, Sverre; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Kvidaland, Haakon Kristian & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2021). Inducible laryngeal obstruction in asthma. European Respiratory Journal. ISSN 0903-1936. doi: 10.1183/13993003.congress-2021.PA1109.
• van der Zanden, Tjitske M.; Mooij, Miriam G.; Vet, Nienke J.; Neubert, Antje; Rascher, Wolfgang & Lagler, Florian B. [Vis alle 11 forfattere av denne artikkelen] (2021). Benefit-Risk Assessment of Off-Label Drug Use in Children: The Bravo Framework. Clinical Pharmacology and Therapeutics. ISSN 0009-9236. 110(4), s. 952–965. doi: 10.1002/cpt.2336.
• Satrell, Emma Elsa Carolina; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Hufthammer, Karl Ove; Thorsen, Einar & Halvorsen, Thomas [Vis alle 7 forfattere av denne artikkelen] (2021). Development of lung diffusion to adulthood following extremely preterm birth. European Respiratory Journal. ISSN 0903-1936. 59(5). doi: 10.1183/13993003.04103-2020. Fulltekst i vitenarkiv
• Andersen, Tiina Maarit; Hov, Brit; Halvorsen, Thomas; Røksund, Ola Drange & Vollsæter, Maria (2021). Upper Airway Assessment and Responses During Mechanically Assisted Cough. Respiratory care. ISSN 0020-1324. 66(7), s. 1196–1213. doi: 10.4187/respcare.08960.
• Sandnes, Astrid; Andersen, Tiina Maarit; Clemm, Hege Synnøve Havstad; Hilland, Magnus; Heimdal, John-Helge & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2021). Clinical responses following inspiratory muscle training in exercise-induced laryngeal obstruction. European Archives of Oto-Rhino-Laryngology. ISSN 0937-4477. doi: 10.1007/s00405-021-07214-5. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to assess laryngeal outcomes shortly after IMT, and to compare self-reported symptoms with a control group 4-6 years later. Methods: Two groups were retrospectively identified from the EILO-register at Haukeland University Hospital, Norway; one group had received only information and breathing advice (IBA), and another additionally IMT (IBA + IMT). At diagnosis, all participants performed continuous laryngoscopy during exercise (CLE), with findings split by glottic and supraglottic scores, and completed a questionnaire mapping exercise-related symptoms. After 2-4 weeks, the IBA + IMT-group was re-evaluated with CLE-test. After 4-6 years, both groups were re-assessed with a questionnaire. Results: We identified 116 eligible patients from the EILO-register. Response rates after 4-6 years were 23/58 (40%) and 32/58 (55%) in the IBA and IBA + IMT-group, respectively. At diagnosis, both groups rated symptoms similarly, but laryngeal scores were higher in the IBA + IMT-group (P = 0.003). After 2-4 weeks, 23/32 in the IBA + IMT-group reported symptom improvements, associated with a decrease of mainly glottic scores (1.7-0.3; P < 0.001), contrasting unchanged scores in the 9/32 without symptom improvements. After 4-6 years, exercise-related symptoms and activity levels had decreased to similar levels in both groups, with no added benefit from IMT; however, full symptom resolution was reported by only 8/55 participants. Conclusion: Self-reported EILO symptoms had improved after 4-6 years, irrespective of initial treatment. Full symptom resolution was rare, suggesting individual follow-up should be offered. Keywords: Dyspnea; Exercise; Inspiratory muscle training; Laryngeal obstruction; Stridor. © 2021. The Author(s).

• Budal, Elisabeth Berge; Ebbing, Cathrine; Kessler, Jørg; Bains, Sukhjeet; Haugen, Olav H. & Aukland, Stein Magnus [Vis alle 10 forfattere av denne artikkelen] (2021). Placental histology predicted adverse outcomes in extremely premature neonates in Norway-population-based study. Acta Paediatrica. ISSN 0803-5253. doi: 10.1111/apa.16198.
• Lie, Astrid Haugen; Grønnevik, Ingvild; Frisk, Bente; Røksund, Ola Drange; Jansrud, Ida & Vollsæter, Maria [Vis alle 8 forfattere av denne artikkelen] (2021). Breathing patterns in people with exercise-induced laryngeal obstruction. Physiological Reports. ISSN 2051-817X. 9(22), s. 1–10. doi: 10.14814/phy2.15086. Fulltekst i vitenarkiv
• Sentenac, Marianne; Benhammou, Valerie; Aden, Ulrika; Ancel, Pierre-Yves; Bakker, Leonhard B & Bakøy, Hannah [Vis alle 31 forfattere av denne artikkelen] (2021). Maternal education and cognitive development in 15 European very-preterm birth cohorts from the RECAP Preterm platform. International Journal of Epidemiology. ISSN 0300-5771. doi: 10.1093/ije/dyab170.
• Hoareau, Laurence; Engelsen, Agnete ; Aanerud, Marianne; Ramnefjell, Maria; Salminen, Pirjo-Riitta & Gärtner, Fabian [Vis alle 9 forfattere av denne artikkelen] (2021). Induction of alveolar and bronchiolar phenotypes in human lung organoids. Physiological Reports. ISSN 2051-817X. doi: 10.14814/phy2.14857.
• Benestad, Merete Røineland; Drageset, Jorunn; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Vollsæter, Maria & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2021). Self-Reported Health in Adolescents With Exercise-Induced Laryngeal Obstruction; A Cross-Sectional Study. Frontiers in pediatrics. ISSN 2296-2360. 9, s. 1–7. doi: 10.3389/fped.2021.617759. Fulltekst i vitenarkiv
• Mikalsen, Ingvild Bruun; Halvorsen, Thomas; Juliusson, Pétur Benedikt; Magnus, Maria Christine; Nystad, Wenche & Stensrud, Trine [Vis alle 9 forfattere av denne artikkelen] (2021). Early life growth and associations with lung function and bronchial hyperresponsiveness at 11-years of age. Respiratory Medicine. ISSN 0954-6111. 177, s. 1–8. doi: 10.1016/j.rmed.2021.106305. Fulltekst i vitenarkiv
• Engan, Mette; Jansrud, Ida; Bekken, Marianne; Halvorsen, Thomas; Fretheim-Kelly, Zoe Louise & Vollsæter, Maria [Vis alle 9 forfattere av denne artikkelen] (2021). Reliability of maximum oxygen uptake in cardiopulmonary exercise testing with continuous laryngoscopy. European Respiratory Journal Open Research (ERJ Open Research). ISSN 2312-0541. 7(1), s. 1–9. doi: 10.1183/23120541.00825-2020. Fulltekst i vitenarkiv
• Kuiper, Ingrid Nordeide; Svanes, Cecilie; Markevych, Iana; Accordini, Simone; Bertelsen, Randi Jacobsen & Bråbäck, Lennart [Vis alle 20 forfattere av denne artikkelen] (2021). Lifelong exposure to air pollution and greenness in relation to asthma, rhinitis and lung function in adulthood. Environment International. ISSN 0160-4120. 146. doi: 10.1016/j.envint.2020.106219. Fulltekst i vitenarkiv
• Tveiten, Lars; Diep, Lien My; Halvorsen, Thomas & Markestad, Trond Jacob (2020). Heart rate during the first 24 hours in term-born infants. Archives of Disease in Childhood: Fetal and Neonatal Edition. ISSN 1359-2998. doi: 10.1136/archdischild-2020-320761. Vis sammendrag

  Objective: Heart rate (HR) is an important clinical parameter in newborn infants, but normal ranges are poorly defined. Our aim was to establish normal reference ranges and individual variations in HR as obtained by auscultation in healthy term-born infants during the first 24 hours of life. Design: Observational study. Setting: Single hospital in Norway. Methods: HR was assessed by auscultation for 30 s at 2, 4, 8, 16 and 24 hours of age. Auscultation was validated against ECG recordings. Subjects: Healthy term-born infants who were asleep or awake in a quiet resting state. Main outcome measures: Construction of percentile curves for resting HR. Results: The study included 953 infants. The 50th percentile was 126 beats per minute (bpm) at age 2 hours and thereafter 120-122 bpm. The respective 2nd and 98th percentiles were 102 (thereafter 96-100) bpm and 162 (thereafter 150-156) bpm. The mean HR was 5.6 bpm higher when awake than asleep, 4.9 bpm higher when on the mother's chest than in the cot, 1.6 bpm higher in girls than in boys, and increased by 0.5 bpm per 0.1°C increase in rectal temperature. Mode of delivery, meconium staining, birth weight and maternal smoking during pregnancy were of no significance. For each infant, HR varied considerably during the first 24 hours (intraclass correlation 0.21 (95% CI 0.18 to 0.24), coefficient of variation 9.2%). Conclusions: The HR percentiles allow for a scientifically based use of HR when assessing newborn infants born at term. Keywords: cardiology; neonatology. © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

• Engan, Mette; Engeseth, Merete Salveson; Fevang, Silje Katrine Elgen; Vollsæter, Maria; Eide, Geir Egil & Røksund, Ola Drange [Vis alle 8 forfattere av denne artikkelen] (2020). Predicting physical activity in a national cohort of children born extremely preterm. Early Human Development. ISSN 0378-3782. 145:105037, s. 1–8. doi: 10.1016/j.earlhumdev.2020.105037. Fulltekst i vitenarkiv
• Kuiper, Ingrid Nordeide; Markevych, Iana; Accordini, Simone; Bertelsen, Randi Jacobsen; Bråbäck, Lennart & Christensen, Jesper Heile [Vis alle 19 forfattere av denne artikkelen] (2020). Associations of preconception exposure to air pollution and greenness with offspring asthma and hay fever. International Journal of Environmental Research and Public Health (IJERPH). ISSN 1661-7827. :5828(16), s. 1–14. doi: 10.3390/ijerph17165828.
• Sautter, Marie; Halvorsen, Thomas; Engan, Mette; Clemm, Hege Havstad & Bentsen, Mariann (2020). Electromagnetic inductance plethysmography to study airflow after nebulized saline in bronchiolitis. Pediatric Pulmonology. ISSN 8755-6863. doi: 10.1002/ppul.25058.
• Duijts, Liesbeth; van Meel, Evelien R.; Moschino, Laura; Baraldi, Eugenio; Barnhoorn, Magda & Bramer, Wichor M. [Vis alle 25 forfattere av denne artikkelen] (2020). European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia. European Respiratory Journal. ISSN 0903-1936. 55(1), s. 1–17. doi: 10.1183/13993003.00788-2019.
• Engeseth, Merete Salveson; Engan, Mette; Clemm, Hege Synnøve Havstad; Vollsæter, Maria; Nilsen, Roy Miodini & Markestad, Trond Jacob [Vis alle 8 forfattere av denne artikkelen] (2020). Voice and Exercise Related Respiratory Symptoms in Extremely Preterm Born Children After Neonatal Patent Ductus Arteriosus. Frontiers in pediatrics. ISSN 2296-2360. 8. doi: 10.3389/fped.2020.00150. Fulltekst i vitenarkiv
• Sørensen, Karen Galta; Øymar, Knut; Dalen, Ingvild; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2019). Lung function and bronchial hyper-reactivity from 11 to 18 years in children with bronchiolitis in infancy . Pediatric Allergy and Immunology. ISSN 0905-6157. 31(1), s. 57–65. doi: 10.1111/pai.13137. Fulltekst i vitenarkiv
• Andersen, Tiina Maarit; Halvorsen, Thomas; Fondenes, Ove; Heimdal, John-Helge; Røksund, Ola Drange & Vollsæter, Maria (2019). Larynx: The Complex Gateway to the Lungs. Respiratory care. ISSN 0020-1324. 64(7). doi: 10.4187/respcare.06989.
• Stangenes, Kristine Marie; Hysing, Mari; Elgen, Irene Bircow; Halvorsen, Thomas; Markestad, Trond Jacob & Bjorvatn, Bjørn (2019). Sleep problems, behavioural problems and respiratory health in children born extremely preterm: a parental questionnaire study . BMJ Paediatrics Open. ISSN 2399-9772. 3:e000534(1), s. 1–7. doi: 10.1136/bmjpo-2019-000534. Fulltekst i vitenarkiv
• Sandnes, Astrid; Hilland, Magnus; Vollsæter, Maria; Andersen, Tiina Maarit; Engesæter, Ingvild Øvstebø & Sandvik, Lorentz [Vis alle 11 forfattere av denne artikkelen] (2019). Severe exercise-induced laryngeal obstruction treated with supraglottoplasty. Frontiers in surgery. ISSN 2296-875X. 6(44), s. 1–9. doi: 10.3389/fsurg.2019.00044. Fulltekst i vitenarkiv
• Fretheim-Kelly, Zoe Louise; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Heimdal, John-Helge & Vollsæter, Maria [Vis alle 8 forfattere av denne artikkelen] (2019). Exercise induced laryngeal obstructions in humans and equines. A comparative review . Frontiers in Physiology. ISSN 1664-042X. 10:1333, s. 1–10. doi: 10.3389/fphys.2019.01333. Fulltekst i vitenarkiv
• Doyle, Lex W.; Andersson, Sture; Bush, Andy; Cheong, Jeanie L.Y.; Clemm, Hege Synnøve Havstad & Evensen, Kari Anne Indredavik [Vis alle 18 forfattere av denne artikkelen] (2019). Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data. The Lancet Respiratory Medicine. ISSN 2213-2600. 7(8), s. 677–686. doi: 10.1016/S2213-2600(18)30530-7. Fulltekst i vitenarkiv
• Engan, Mette; Vollsæter, Maria; Øymar, Knut; Markestad, Trond; Eide, Geir Egil & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2019). Comparison of physical activity and body composition in a cohort of children born extremely preterm or with extremely low birth weight to matched term-born controls: a follow-up study. BMJ Paediatrics Open. ISSN 2399-9772. 3:e000481, s. 1–11. doi: 10.1136/bmjpo-2019-000481. Fulltekst i vitenarkiv
• Naumburg, Estelle; Rane, Anders; Halvorsen, Thomas; Glosli, Heidi; Henriksen, Tine Brink & Haraldsson, Àsgeir [Vis alle 8 forfattere av denne artikkelen] (2019). Tardy development of safe medicines for children: a Nordic network offers new platform to reduce this inequity. Acta Paediatrica. ISSN 0803-5253. 108(6), s. 992–993. doi: 10.1111/apa.14775.
• Sandnes, Astrid; Andersen, Tiina Maarit; Clemm, Hege Synnøve Havstad; Hilland, Magnus; Vollsæter, Maria & Heimdal, John-Helge [Vis alle 9 forfattere av denne artikkelen] (2019). Exercise-induced laryngeal obstruction in athletes treated with inspiratory muscle training. BMJ Open sport & exercise medicine. ISSN 2055-7647. 5(1), s. 1–8. doi: 10.1136/bmjsem-2018-000436. Fulltekst i vitenarkiv
• Fretheim-Kelly, Zoe; Halvorsen, Thomas; Heimdal, John-Helge; Strand, Eric; Vollsæter, Maria & Clemm, Hege Synnøve Havstad [Vis alle 7 forfattere av denne artikkelen] (2019). Feasibility and tolerability of measuring translaryngeal pressure during exercise. The Laryngoscope. ISSN 0023-852X. 129, s. 2748–2753. doi: 10.1002/lary.27846. Fulltekst i vitenarkiv
• Clemm, Hege Synnøve Havstad; Sandnes, Astrid; Vollsæter, Maria; Hilland, Magnus; Heimdal, John-Helge & Røksund, Ola Drange [Vis alle 7 forfattere av denne artikkelen] (2018). The Heterogeneity of Exercise-induced Laryngeal Obstruction. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 197(8), s. 1068–1069. doi: 10.1164/rccm.201708-1646IM.
• Andersen, Tiina Maarit; Sandnes, Astrid; Fondenes, Ove; Nilsen, Roy Miodini; Tysnes, Ole-Bjørn & Heimdal, John-Helge [Vis alle 10 forfattere av denne artikkelen] (2018). Laryngeal responses to mechanically assisted cough in progressing amyotrophic lateral sclerosis. Respiratory care. ISSN 0020-1324. 63(5), s. 538–549. doi: 10.4187/respcare.05924.
• Vollsæter, Maria; Halvorsen, Thomas; Markestad, Trond; Øymar, Knut; Ueland, Per Magne & Meyer, Klaus [Vis alle 8 forfattere av denne artikkelen] (2018). Renal function and blood pressure in 11 year old children born extremely preterm or small for gestational age. PLOS ONE. ISSN 1932-6203. 13:e0205558(10), s. 1–11. doi: 10.1371/journal.pone.0205558.
• Kotecha, Sailesh; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas & Kotecha, Sarah J. (2018). Bronchial hyper-responsiveness in preterm-born subjects: A systematic review and meta-analysis. Pediatric Allergy and Immunology. ISSN 0905-6157. 29(7), s. 715–725. doi: 10.1111/pai.12957.
• Stangenes, Kristine Marie; Hysing, Mari; Fevang, Silje Katrine Elgen; Elgen, Irene Bircow; Halvorsen, Thomas & Markestad, Trond [Vis alle 7 forfattere av denne artikkelen] (2018). Prenatal and neonatal factors predicting sleep problems in children born extremely preterm or with extremely low birthweight. Frontiers in pediatrics. ISSN 2296-2360. 6:178, s. 1–9. doi: 10.3389/fped.2018.00178.
• Skromme, Kaia; Vollsæter, Maria; Øymar, Knut; Markestad, Trond & Halvorsen, Thomas (2018). Respiratory morbidity through the first decade of life in a national cohort of children born extremely preterm. BMC Pediatrics. ISSN 1471-2431. 18:102, s. 1–13. doi: 10.1186/s12887-018-1045-7.
• Bentsen, Mariann; Markestad, Trond & Halvorsen, Thomas (2018). Ventilator flow data predict bronchopulmonary dysplasia in extremely premature neonates. ERS Monograph. ISSN 2312-508X. 4:00099-2017, s. 1–7. doi: 10.1183/23120541.00099-2017.
• Røksund, Ola Drange; Olin, James Tod & Halvorsen, Thomas (2018). Working towards a common transatlantic approach for evaluation of exercise-induced laryngeal obstruction. Immunology and allergy clinics of North America. ISSN 0889-8561. 38(2), s. 281–292. doi: 10.1016/j.iac.2018.01.002. Fulltekst i vitenarkiv
• Clemm, Hege Synnøve Havstad; Engeseth, Merete Salveson; Vollsæter, Maria; Kotecha, Sailesh & Halvorsen, Thomas (2018). Bronchial hyper-responsiveness after preterm birth. Paediatric Respiratory Reviews. ISSN 1526-0542. 26, s. 34–40. doi: 10.1016/j.prrv.2017.06.010. Fulltekst i vitenarkiv
• Halvorsen, Thomas; Walsted, Emil Schwarz; Bucca, Caterina; Bush, Andrew; Cantarella, Giovanna & Friedrich, Gerhard [Vis alle 15 forfattere av denne artikkelen] (2017). Inducible laryngeal obstruction: An official joint European Respiratory Society and European Laryngological Society statement. European Respiratory Journal. ISSN 0903-1936. 50(3). doi: 10.1183/13993003.02221-2016.
• Engeseth, Merete Salveson; Olsen, Nina Rydland; Mæland, Silje; Halvorsen, Thomas; Goode, Adam & Røksund, Ola Drange (2017). Left vocal cord paralysis after patent ductus arteriosus ligation: A systematic review. Paediatric Respiratory Reviews. ISSN 1526-0542. 27, s. 74–85. doi: 10.1016/j.prrv.2017.11.001. Fulltekst i vitenarkiv
• Bentsen, Mariann; Satrell, Emma ; Reigstad, Hallvard; Johnsen, Synnøve Lian; Vollsæter, Maria & Røksund, Ola Drange [Vis alle 10 forfattere av denne artikkelen] (2017). Mid-childhood outcomes after pre-viable preterm premature rupture of membranes. Journal of Perinatology. ISSN 0743-8346. 37(9), s. 1053–1059. doi: 10.1038/jp.2017.97.
• Bentsen, Mariann; Markestad, Trond; Øymar, Knut & Halvorsen, Thomas (2017). Lung function at term in extremely preterm-born infants: A regional prospective cohort study. BMJ Open. ISSN 2044-6055. 7:e016868(10), s. 1–10. doi: 10.1136/bmjopen-2017-016868.
• Hestnes, Julie ; Hoel, Hedda Benedicte; Risa, Ole Johan; Romstøl, Hanna Omholt; Røksund, Ola Drange & Frisk, Bente [Vis alle 9 forfattere av denne artikkelen] (2017). Ventilatory efficiency in children and adolescents born extremely preterm. Frontiers in Physiology. ISSN 1664-042X. 8. doi: 10.3389/fphys.2017.00499. Fulltekst i vitenarkiv
• Bentsen, Mariann; Eriksen, Morten; Olsen, Merete Susan; Markestad, Trond & Halvorsen, Thomas (2016). Electromagnetic inductance plethysmography is well suited to measure tidal breathing in infants. ERS Monograph. ISSN 2312-508X. 2:00062(4). doi: 10.1183/23120541.00062-2016.
• Monsen, Anne Lise Bjørke; Vollsæter, Maria; Ueland, Per Magne; Markestad, Trond; Øymar, Knut & Halvorsen, Thomas (2016). Increased bronchial hyperresponsiveness and higher asymmetric dimethylarginine levels after fetal growth restriction. American Journal of Respiratory Cell and Molecular Biology. ISSN 1044-1549. 56(1), s. 83–89. doi: 10.1165/rcmb.2016-0210OC.
• Engeseth, Merete Salveson; Olsen, Nina Rydland; Røksund, Ola Drange; Mæland, Silje; Goode, Adam P. & Halvorsen, Thomas (2016). A systematic review and meta-analysis: Prevalence and consequences of left recurrent laryngeal nerve paresis following surgical ligation of patent ductus arteriosus in extremely premature infants. PROSPERO 2016:CRD42016029921 Available from http://www.crd.york.ac.uk/PROSPERO_REBRANDING/display_record.asp?ID=CRD42016029921. Prospero: a journal of new thinking in philosophy for education. ISSN 1358-6785.
• Tveiten, Lars; Diep, Lien My; Halvorsen, Thomas & Markestad, Trond (2016). Respiratory rate during the first 24 hours of life in healthy term infants. Pediatrics. ISSN 0031-4005. 137:e20152326(4). doi: 10.1542/peds.2015-2326.
• Røksund, Ola Drange; Heimdal, John-Helge; Clemm, Hege Synnøve Havstad; Vollsæter, Maria & Halvorsen, Thomas (2016). Exercise inducible laryngeal obstruction: diagnostics and management. Paediatric Respiratory Reviews. ISSN 1526-0542. 21, s. 86–94. doi: 10.1016/j.prrv.2016.07.003. Fulltekst i vitenarkiv
• Hilland, Magnus; Røksund, Ola Drange; Sandvik, Lorentz; Haaland, Øystein Ariansen; Aarstad, Hans Jørgen & Halvorsen, Thomas [Vis alle 7 forfattere av denne artikkelen] (2016). Congenital laryngomalacia is related to exerciseinduced laryngeal obstruction in adolescence. Archives of Disease in Childhood. ISSN 0003-9888. 101(5), s. 443–448. doi: 10.1136/archdischild-2015-308450.
• Vollsæter, Maria; Clemm, Hege Synnøve Havstad; Satrell, Emma Elsa Carolina; Eide, Geir Egil; Røksund, Ola Drange & Markestad, Trond [Vis alle 7 forfattere av denne artikkelen] (2015). Adult respiratory outcomes of extreme preterm birth. A regional cohort study. Annals of the American Thoracic Society. ISSN 2329-6933. 12(3), s. 313–322. doi: 10.1513/AnnalsATS.201406-285OC. Vis sammendrag

  Rationale: Lifetime respiratory function after extremely preterm birth (gestational age ≤28 wk or birth weight ≤1,000 g) is unknown. Objectives: To compare changes from 18–25 years of age in respiratory health, lung function, and airway responsiveness in young adults born extremely prematurely to that of term-born control subjects. Methods: Comprehensive lung function investigations and interviews were conducted in a population-based sample of 25-year-old subjects born extremely prematurely in western Norway in 1982–1985, and in matched term-born control subjects. Comparison was made to similar data collected at 18 years of age. Measurements and Main Results: At 25 years of age, 46/51 (90%) eligible subjects born extremely prematurely and 39/46 (85%) control subjects participated. z-Scores for FEV1, forced expiratory flow at 25–75% of vital capacity, and FEV1/FVC were significantly reduced in subjects born extremely prematurely by 1.02, 1.26, and 0.88, respectively, and airway resistance (kPa/L/s) was increased (0.23 versus 0.18). Residual volume to total lung capacity increased with severity of neonatal bronchopulmonary dysplasia. Responsiveness to methacholine (dose–response slope; 3.16 versus 0.85) and bronchial lability index (7.5 versus 4.8%) were increased in subjects born extremely prematurely. Lung function changes from 18 to 25 years and respiratory symptoms were similar in the prematurely born and term-born groups. Conclusions: Lung function in early adult life was in the normal range in the majority of subjects born extremely prematurely, but methacholine responsiveness was more pronounced than in term-born young adults, suggesting a need for ongoing pulmonary monitoring in this population

Se alle arbeider i Cristin

• Halvorsen, Thomas (2024). Ambient Air Pollution and Morbidities in Bronchopulmonary Dysplasia; It’s All about the Money. Annals of the American Thoracic Society. ISSN 2329-6933. 21(1), s. 34–36. doi: 10.1513/AnnalsATS.202310-893ED.
• Brekka, Anne Kristine; Ntoumenopoulos, George; Røksund, Ola Drange; Engeseth, Merete Salveson; Engeset, Merete Salveson & Clemm, Hege Synnøve Havstad [Vis alle 9 forfattere av denne artikkelen] (2023). Strupens responser under non-invasiv ventilasjonsstøtte hos friske frivillige.
• Leong, Paul; Hull, James H.; Gibson, Peter G.; Halvorsen, Thomas & Bardin, Philip G. (2023). Reply. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. doi: 10.1016/j.jaci.2023.08.027.
• Bårdsen, Tonje; Røksund, Ola Drange; Eagan, Tomas Mikal Lind; Hufthammer, Karl Ove; Benestad, Merete Røineland & Clemm, Hege Synnøve Havstad [Vis alle 8 forfattere av denne artikkelen] (2023). Impaired Lung Function in Extremely Preterm-Born Adults in Their Fourth Decade of Life. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 208(4), s. 493–495. doi: 10.1164/rccm.202303-0448LE. Fulltekst i vitenarkiv
• Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2023). Blood eosinophils during bronchiolitis were not associated with adult asthma in a Norwegian cohort study. Acta Paediatrica. ISSN 0803-5253. doi: 10.1111/apa.16710.
• Andersen, Tiina Maarit; Fondenes, Ove; Røksund, Ola Drange; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas & Vollsæter, Maria (2022). From bedside to bench - In vivo and in vitro evaluation of mechanically assisted cough treatment in a patient with bulbar Amyotrophic Lateral Sclerosis. Respiratory Medicine Case Reports. 37, s. 1–4. doi: 10.1016/j.rmcr.2022.101649.
• Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Halvorsen, Thomas & Mikalsen, Ingvild Bruun (2020). Reply to Korppi and Riikonen. Pediatric Allergy and Immunology. ISSN 0905-6157. 31(6), s. 720–721. doi: 10.1111/pai.13272.
• Engan, Mette; Engeset, Merete Salveson; Engesæter, Ingvild Øvstebø; Gamlemshaug, Ole C. O.; Vollsæter, Maria & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2020). Prevalence and consequences of left vocal cord paralysis in young adults born extremely premature with a history of neonatal patent ductus arteriosus surgery.
• Halvorsen, Thomas; Clemm, Hege Havstad; Vollsæter, Maria & Røksund, Ola Drange (2020). Conundrums of exercise-related breathing problems. Epiglottic, laryngeal, or bronchial obstruction? American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X. 202(10), s. e142–e143. doi: 10.1164/rccm.201910-1921IM.
• Engeseth, Merete Salveson; Engan, Mette; Clemm, Hege Synnøve Havstad; Nilsen, Roy Miodini; Vollsæter, Maria & Halvorsen, Thomas [Vis alle 7 forfattere av denne artikkelen] (2019). Respiratory- and voice symptoms among extremely preterm born children with prolonged ventilator dependency. A Norwegian national cohort study. .
• Jansrud, Ida; Bovim, Lars Peder Vatshelle; Vollsæter, Maria; Røksund, Ola Drange; Halvorsen, Thomas & Clemm, Hege Synnøve Havstad (2018). Is continuous laryngoscopy during cardiopulmonary exercise testing reliable for measuring maximum oxygen uptake?
• Røksund, Ola Drange; Halvorsen, Thomas & Heimdal, John-Helge (2018). Heterogeniteten ved anstrengelsesutløst laryngeal obstruksjon. BestPractice. Lungemedisin. s. 22–26.
• Andersen, Tiina Maarit; Sandnes, Astrid; Fondenes, Ove; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas & Nilsen, Roy Miodini [Vis alle 10 forfattere av denne artikkelen] (2018). Laryngoscopy Can Be a Valuable Tool for Unexpected Therapeutic Response in Noninvasive Respiratory Interventions. Respiratory care. ISSN 0020-1324. 63(11), s. 1459–1461. doi: 10.4187/respcare.06674.
• Halvorsen, Thomas (2018). Our tiny preemies: What will become of their future pulmonary health? Annals of the American Thoracic Society. ISSN 2329-6933. 15(11), s. 1276–1278. doi: 10.1513/AnnalsATS.201808-579ED.
• Engeseth, Merete Salveson; Maeland, Silje; Vollsæter, Maria; Clemm, Hege; Engan, Mette & Halvorsen, Thomas [Vis alle 7 forfattere av denne artikkelen] (2018). Symptoms of vocal cord paresis among children born extremely premature with- or without a PDA ligation. .
• Øymar, Knut; Mikalsen, Ingvild Bruun; Nag, Torbjørn; Halvorsen, Thomas & Crowley, Suzanne (2017). Systemiske steroider til førskolebarn med symptomer fra nedre luftveier. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 137(10), s. 698–699. doi: 10.4045/tidsskr.17.0245.
• Engeseth, Merete Salveson; Røksund, Ola Drange; Vollsæter, Maria; Halvorsen, Thomas & Clemm, Hege Synnøve Havstad (2016). Respiratory morbidity in extremely premature born children and later physical Activity. .
• Hestnes, Julie; Hoel, Hedda B; Røksund, Ola Drange; Frisk, Bente; Thorsen, Einar & Halvorsen, Thomas [Vis alle 8 forfattere av denne artikkelen] (2016). Ventilatory efficiency in children and adolescents born extremely preterm. European Respiratory Journal. ISSN 0903-1936. 48. doi: 10.1183/13993003.congress-2016.PA1223.
• Røksund, Ola Drange; Heimdal, John-Helge & Halvorsen, Thomas (2016). Anstrengelsesutløst laryngeal obstruksjon - diagnostikk og behandling. Best Practice Lungemedisin i Norge. november(22), s. 22–25.
• Fretheim-Kelly, Zoe; Strand, Eric; Fintl, Constanze; Heimdal, John-Helge; Halvorsen, Thomas & Røksund, Ola Drange (2021). From horses to humans: a comparative study developing the first protocol for measuring upper airway pressures in exercising humans. Norwegian University of Life Sciences. ISSN 978-82-575-1814-1. 2021(44).
• Bentsen, Mariann; Halvorsen, Thomas; Markestad, Trond & Øymar, Knut (2018). Tidal breathing parameters in extremely premature infants. Feasibility and clinical utility of electromagnetic inductance plethysmography. Universitetet i Bergen. ISSN 978-82-308-3683-5.
• Andersen, Tiina Maarit; Røksund, Ola Drange; Halvorsen, Thomas; Heimdal, John-Helge; Tysnes, Ole-Bjørn & Vollsæter, Maria [Vis alle 7 forfattere av denne artikkelen] (2018). Laryngeal response patterns during mechanically assisted cough in Amyotrophic Lateral Sclerosis. Universitetet i Bergen. ISSN 978-82-308-3718-4.
• Vollsæter, Maria & Halvorsen, Thomas (2016). Long-term Respiratory Outcomes of Extreme Preterm Birth. A regional cohort study. Universitetet i Bergen. ISSN 978-82-308-3348-3.

Se alle arbeider i Cristin